Statement 1 is correct: It is necessary to put proper effluent treatment protocols in place.

This statement reflects the importance of addressing the environmental impact of antibiotics manufacturing companies not treating their waste. Implementing proper effluent treatment protocols can help reduce pollution and prevent the rise of drug-resistant infections.

Statement 2 is incorrect: It is necessary to promote environmental awareness among people.

While promoting environmental awareness is important, the primary focus should be on implementing concrete solutions such as effluent treatment protocols to address the pollution caused by antibiotics manufacturing companies.

Statement 3 is incorrect: Spread of drug-resistant bacteria cannot be done away with, as it is inherent in modern medical care.

While drug-resistant bacteria are a challenge in modern medical care, the passage highlights the role of pollution from antibiotics factories in fueling their rise. Efforts to address pollution and implement proper waste treatment can help mitigate the spread of drug-resistant infections.

Statement 4 is incorrect: Pharma-manufacturing companies should be set up in remote rural areas, away from crowded towns and cities.

While locating pharmaceutical manufacturing plants in remote rural areas may reduce the impact on populated areas, the focus should be on implementing proper waste treatment protocols regardless of the location of the companies. Effluent treatment is key to addressing the environmental impact of antibiotics manufacturing.